Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylbutazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylbutazone SCHEMBL8005041 | 0.91 | RAB9A (0.82) | ALDH1A1LMNACYP3A4PTGS1HPGD | |
| Phenylbutazone SCHEMBL3632 | 0.91 | RAB9A (0.82) | ALDH1A1LMNACYP3A4PTGS1HPGD | |
| Phenylbutazone SCHEMBL2874252 | 0.89 | RAB9A (0.80) | ALDH1A1LMNACYP3A4PTGS1HPGD | |
| Phenylbutazone SCHEMBL21694456 | 0.89 | RAB9A (0.80) | ALDH1A1LMNACYP3A4PTGS1HPGD | |
| Phenylbutazone SCHEMBL7715162 | 0.89 | RAB9A (0.80) | ALDH1A1LMNACYP3A4PTGS1HPGD | |
| Phenylbutazone SCHEMBL2122724 | 0.89 | RAB9A (0.80) | ALDH1A1LMNACYP3A4PTGS1HPGD | |
| Phenylbutazone SCHEMBL10913190 | 0.89 | RAB9A (0.80) | ALDH1A1LMNACYP3A4PTGS1HPGD | |
| SCHEMBL4909796 | 0.86 | CYP3A4 (0.71) | ALDH1A1LMNACYP3A4PTGS1HPGD | |
| SCHEMBL29489697 | 0.84 | ALDH1A1 (0.73) | ALDH1A1LMNACYP3A4PTGS1HPGD | |
| Phenylbutazone SCHEMBL11269971 | 0.84 | ALDH1A1 (0.72) | ALDH1A1LMNACYP3A4PTGS1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115751-A4 | PHOTOPOLYMERIZATION PROCESS AND COMPOSITION EMPLOYING A CHARGE TRANSFER COMPLEX AND CATIONIC PHOTOINITIATOR | FUSION UV SYS INC (US) | 2002-08-14 | — | — | EP | disclosed |
| EP-1115751-A1 | PHOTOPOLYMERIZATION PROCESS AND COMPOSITION EMPLOYING A CHARGE TRANSFER COMPLEX AND CATIONIC PHOTOINITIATOR | Fusion Uv Systems, Inc. (US) | 2001-07-18 | — | — | EP | disclosed |
| US-6127447-A | RADIATION CURABLE COATING COMPOSITION INCLUDES AN EFFECTIVE AMOUNT OF CATIONIC PHOTOINITIATOR IN COMBINATION WITH A CHARGE TRANSFER COMPLEX | FUSION UV SYSTEMS, INC. (US) | 2000-10-03 | — | — | US | disclosed |
| WO-2000006613-A1 | PHOTOPOLYMERIZATION PROCESS AND COMPOSITION EMPLOYING A CHARGE TRANSFER COMPLEX AND CATIONIC PHOTOINITIATOR | FUSION UV SYSTEMS, INC. (US) | 2000-02-10 | — | — | WO | disclosed |