Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467945 | 0.89 | AKR1B1 (0.39) | GAAMAPTSMN1; SMN2HPGDHDAC6 | |
| SCHEMBL7470720 | 0.83 | PSEN1 (0.43) | SMN1; SMN2HPGDHDAC6HDAC1HDAC8 | |
| SCHEMBL8705102 | 0.82 | GAA (0.38) | GAAMAPTPOLBSMN1; SMN2TDP1 | |
| SCHEMBL7467388 | 0.81 | PSEN1 (0.42) | HPGDHDAC6HDAC1HDAC8PSEN1 | |
| SCHEMBL7472637 | 0.80 | MEN1 (0.40) | GAAMAPTPOLBSMN1; SMN2TDP1 | |
| SCHEMBL7472835 | 0.80 | SMN1; SMN2 (0.43) | MAPTSMN1; SMN2HPGDHDAC6HDAC1 | |
| Iodide SCHEMBL7464178 | 0.80 | MAPT (0.37) | GAAMAPTSMN1; SMN2 | |
| SCHEMBL7472701 | 0.79 | PSEN1 (0.42) | SMN1; SMN2HDAC6HDAC1HDAC8L3MBTL1 | |
| SCHEMBL7461621 | 0.79 | KDM4E (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7465212 | 0.78 | PPARG (0.43) | MAPTSMN1; SMN2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |