Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | PARG | Q86W56 | 2/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468017 | 0.91 | HDAC6 (0.45) | SMN1; SMN2HPGDHDAC6HDAC1HDAC8 | |
| SCHEMBL7472478 | 0.85 | CCR2 (0.50) | SMN1; SMN2HPGDHDAC6HDAC1HDAC8 | |
| SCHEMBL7466686 | 0.84 | CYP3A4 (0.38) | SMN1; SMN2HPGDHDAC6HDAC1HDAC8 | |
| SCHEMBL7467945 | 0.84 | AKR1B1 (0.39) | SMN1; SMN2HPGDHDAC6HDAC1HDAC8 | |
| SCHEMBL7465634 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2HPGDHDAC6HDAC1HDAC8 | |
| SCHEMBL7467191 | 0.80 | L3MBTL1 (0.45) | SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL7460868 | 0.80 | GAA (0.36) | SMN1; SMN2HPGDHDAC6HDAC1HDAC8 | |
| SCHEMBL7460713 | 0.80 | MAPK8 (0.55) | SMN1; SMN2HPGDHDAC6HDAC1HDAC8 | |
| SCHEMBL8705102 | 0.78 | GAA (0.38) | SMN1; SMN2HPGDMAPTKDM4ENOD2 | |
| SCHEMBL7461866 | 0.78 | MEN1 (0.48) | SMN1; SMN2MAPTKDM4EMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |