SCHEMBL7461007

SCHEMBL7461007

COc1cccc(NCc2cscc2-c2cc(N)ccc2N)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.43
ACHE P22303 1/20 0.43
NOS1 P29475 1/20 0.42
IDH1 O75874 1/20 0.40
KMT2A Q03164 3/20 0.40
MEN1 O00255 2/20 0.40
MAPT P10636 2/20 0.40
KDM4E B2RXH2 1/20 0.40
HTT P42858 1/20 0.40
ALDH1A1 P00352 1/20 0.39
CYP3A4 P08684 1/20 0.39
TP53 P04637 1/20 0.39
POLB P06746 1/20 0.39
MAPK1 P28482 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
ROCK2 O75116 1/20 0.38
GRK2 P25098 1/20 0.38
HDAC1 Q13547 1/20 0.38
MTNR1A P48039 1/20 0.38
MTNR1B P49286 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7460964 0.99 BCHE (0.42) BCHEACHENOS1IDH1KMT2A
SCHEMBL7455072 0.87 RPS6KA2 (0.46) BCHEACHEKMT2AMEN1MAPT
Hydrochloric Acid SCHEMBL7457249 0.86 RPS6KA2 (0.46) BCHEACHEKMT2AMEN1MAPT
SCHEMBL7460493 0.83 ADRA2B (0.37) KMT2AMEN1MAPTKDM4EHTT
SCHEMBL7459718 0.83 KDM4E (0.47) KMT2AMEN1MAPTKDM4EALDH1A1
Hydrochloric Acid SCHEMBL7461580 0.82 KDM4E (0.46) KMT2AMEN1MAPTKDM4EALDH1A1
SCHEMBL7463058 0.82 MAPT (0.42) KMT2AMEN1MAPTKDM4EALDH1A1
Hydrochloric Acid SCHEMBL7455787 0.82 ADRA2B (0.36) KMT2AMEN1MAPTKDM4EHTT
SCHEMBL6268509 0.81 NOS1 (0.50) BCHEACHENOS1IDH1KMT2A
SCHEMBL7460974 0.81 MEN1 (0.38) KMT2AMEN1MAPTKDM4EALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0963982-B1 New diaminobenzene derivatives and these componends containing colouring agents WELLA AG (DE) 2002-03-13 EP claimed
US-6132475-A FOR OXIDATION DYEING OF KERATIN FIBERS; INCLUDES COUPLER AND DEVELOPER, IN WHICH THE DEVELOPER IS A SUBSTITUTED 2-(FURYL, THIENYL, PYRROLYL, OR SELENOPHENE) P-DIAMINOBENZENE DERIVATIVE OF GIVEN FORMULA; COLORFASTNESS, WASHFASTNESS WELLA AKTIENGESELLSCHAFT (DE) 2000-10-17 US claimed
EP-0963982-A2 New diaminobenzene derivatives and these componends containing colouring agents Wella Aktiengesellschaft (DE) 1999-12-15 EP claimed
EP-0963982-B1 New diaminobenzene derivatives and these componends containing colouring agents WELLA AG (DE) 2002-03-13 EP disclosed
US-6132475-A FOR OXIDATION DYEING OF KERATIN FIBERS; INCLUDES COUPLER AND DEVELOPER, IN WHICH THE DEVELOPER IS A SUBSTITUTED 2-(FURYL, THIENYL, PYRROLYL, OR SELENOPHENE) P-DIAMINOBENZENE DERIVATIVE OF GIVEN FORMULA; COLORFASTNESS, WASHFASTNESS WELLA AKTIENGESELLSCHAFT (DE) 2000-10-17 US disclosed
EP-0963982-A2 New diaminobenzene derivatives and these componends containing colouring agents Wella Aktiengesellschaft (DE) 1999-12-15 EP disclosed