Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7461907 | 0.86 | PKM (0.55) | PKMHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7461773 | 0.85 | PKM (0.54) | PKMHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7456859 | 0.83 | PKM (0.52) | PKMNPC1RAB9AMITFLMNA | |
| SCHEMBL7462408 | 0.82 | PIM1 (0.56) | HPGDPOLB | |
| SCHEMBL7462410 | 0.82 | PIM1 (0.56) | HPGDPOLB | |
| SCHEMBL6953753 | 0.81 | PKM (0.53) | PKMHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6953750 | 0.81 | PKM (0.53) | PKMHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5380567 | 0.78 | RAB9A (0.77) | PKMNPC1RAB9ASMN1; SMN2MITF | |
| SCHEMBL5935593 | 0.76 | MEN1 (0.55) | HPGDSMN1; SMN2LMNAKMT2AMAPT | |
| SCHEMBL8158054 | 0.75 | PKM (0.53) | PKMHPGDNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971917-B1 | THIAZOLIDINEDIONE AND OXAZOLIDINEDIONE DERIVATIVES HAVING ANTIDIABETIC, HYPOLIPIDAEMIC AND ANTIHYPERTENSIVE PROPERTIES | REDDY RESEARCH FOUNDATION (IN) | 2002-02-06 | — | — | EP | disclosed |
| US-6011036-A | Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2000-01-04 | — | — | US | disclosed |