Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8530390 | 0.90 | SMN1; SMN2 (0.32) | SMN1; SMN2HPGDHTTALDH1A1MEN1 | |
| SCHEMBL16577619 | 0.70 | MEN1 (0.44) | SMN1; SMN2HPGDHTTALDH1A1MEN1 | |
| SCHEMBL24287571 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDHTTALDH1A1MEN1 | |
| SCHEMBL23615406 | 0.67 | SMN1; SMN2 (0.53) | SMN1; SMN2HPGDHTTALDH1A1MEN1 | |
| SCHEMBL888672 | 0.66 | MEN1 (0.50) | SMN1; SMN2HPGDHTTALDH1A1MEN1 | |
| SCHEMBL8829446 | 0.66 | FAAH (0.53) | SMN1; SMN2HPGDHTTALDH1A1MEN1 | |
| SCHEMBL24829524 | 0.66 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDHTTALDH1A1MEN1 | |
| SCHEMBL21322473 | 0.66 | SMN1; SMN2 (0.55) | SMN1; SMN2HPGDHTTALDH1A1MEN1 | |
| Methacrylic Acid SCHEMBL31065394 | 0.66 | ALDH1A1 (0.39) | SMN1; SMN2HPGDHTTALDH1A1MEN1 | |
| SCHEMBL7463384 | 0.65 | PTGS1 (0.58) | SMN1; SMN2HPGDHTTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874842-B1 | MERCAPTOALKYLPEPTIDYL COMPOUNDS HAVING AN IMIDAZOLE SUBSTITUENT AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES (MMP) AND/OR TUMOUR NECROSIS FACTOR (TNF) | DARWIN DISCOVERY LTD (GB) | 2002-04-10 | — | — | EP | disclosed |