SCHEMBL7461933

SCHEMBL7461933

Cn1c(C(F)(F)F)cc(=O)n(-c2ccc3snc(COC(=O)c4ccccc4)c3c2)c1=O

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.34
TDP1 Q9NUW8 3/20 0.33
ALDH1A1 P00352 3/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
ALOX15 P16050 1/20 0.33
POLB P06746 3/20 0.33
CMA1 P23946 2/20 0.32
SMN1; SMN2 Q16637 3/20 0.32
TP53 P04637 1/20 0.32
GAA P10253 1/20 0.32
MPI P34949 1/20 0.32
EP300 Q09472 1/20 0.32
PHOSPHO1 Q8TCT1 1/20 0.32
KAT2A Q92830 1/20 0.32
KAT2B Q92831 1/20 0.32
KMT2A Q03164 4/20 0.31
SLC6A2 P23975 1/20 0.31
SLC6A3 Q01959 1/20 0.31
MEN1 O00255 3/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7460342 0.85
SCHEMBL7460879 0.85 PKM (0.34) POLBCMA1GAA
SCHEMBL7460673 0.84 POLB (0.33) MAPTPOLBGAA
SCHEMBL7461878 0.83 AKR1B1 (0.35) ALDH1A1POLBCMA1GAACTSG
SCHEMBL7457048 0.83 MAOB (0.42) ALDH1A1SMN1; SMN2
SCHEMBL7454776 0.82 MCHR1 (0.31)
SCHEMBL7459512 0.82 MAPT (0.30) MAPT
SCHEMBL6771342 0.82 ALDH1A1 (0.31) ALDH1A1
SCHEMBL7467618 0.82
SCHEMBL7468072 0.82

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0908457-B1 3-(1,2-benzisothiazol- and isoxazol-5-Y1)-2,4(1H,3H)-pyrimidinedione or thione and 3-(1,2-benzisothiazol- and isoxazol-5-y1)-4(3H)-pyrimidinone or thione herbicidal agents BASF AG (DE) 2002-11-13 EP claimed