Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.73 |
| ▸ | JAK3 | P52333 | 1/20 | 0.73 |
| ▸ | PLK1 | P53350 | 1/20 | 0.59 |
| ▸ | SYK | P43405 | 7/20 | 0.58 |
| ▸ | IKBKB | O14920 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | GPR39 | O43194 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470116 | 0.89 | JAK2 (0.68) | JAK2JAK3PLK1SYKAURKA | |
| SCHEMBL4901743 | 0.85 | JAK2 (0.54) | JAK2JAK3SYKIKBKBKIT | |
| SCHEMBL4383820 | 0.84 | JAK2 (1.00) | JAK2JAK3PLK1IKBKBHDAC1 | |
| SCHEMBL4378143 | 0.83 | JAK2 (0.90) | JAK2JAK3PLK1IKBKBHDAC1 | |
| SCHEMBL4903298 | 0.83 | ABL1 (0.59) | JAK2JAK3SYKAURKA | |
| SCHEMBL4899630 | 0.82 | ABL1 (0.64) | JAK2HDAC1 | |
| SCHEMBL4903032 | 0.82 | MAPK8 (0.74) | JAK2SYKIKBKBAURKA | |
| SCHEMBL7470857 | 0.81 | ABL1 (0.63) | JAK2JAK3SYKIKBKBAURKA | |
| SCHEMBL4899326 | 0.81 | PDGFRB (0.56) | JAK2SYKAURKAHDAC1 | |
| SCHEMBL7465651 | 0.81 | ABL1 (0.76) | JAK2JAK3PLK1IKBKBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |
| US-4876252-A | ADMINISTERING ANTIASTHMATIC OR ANTIALLERGEN | AMERICAN CYANAMID COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | disclosed |