Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12306207 | 0.89 | HSP90AA1 (0.59) | ADORA1ADORA2ACHRNA7HSP90AA1HSP90AB1 | |
| SCHEMBL7462060 | 0.86 | MAOB (0.56) | ADORA1ADORA2ACHRNA7HSP90AA1HSP90AB1 | |
| SCHEMBL17144826 | 0.81 | CYP1A1 (0.54) | CYP1A1CYP1B1PDGFRBTLR9FYN | |
| SCHEMBL7598921 | 0.75 | CYP1A1 (0.61) | CYP1A1CYP1B1TLR9TLR7MAPT | |
| SCHEMBL30507464 | 0.74 | GSK3B (0.60) | CHRNA7HSP90AA1HSP90AB1CYP1A1CYP1B1 | |
| SCHEMBL28512792 | 0.74 | GSK3B (0.60) | CHRNA7HSP90AA1HSP90AB1CYP1A1CYP1B1 | |
| SCHEMBL13952628 | 0.73 | TUBB4A (0.55) | ACHECYP1A1CYP1B1FYNMAPT | |
| SCHEMBL10486300 | 0.73 | NPC1 (0.71) | ADORA1ADORA2AHSP90AA1HSP90AB1CYP1A1 | |
| SCHEMBL8592873 | 0.71 | KDM4E (0.50) | ADORA1ADORA2AHSP90AA1HSP90AB1CYP1A1 | |
| SCHEMBL12306204 | 0.70 | KDM4E (0.63) | ADORA1ADORA2ACYP1A1CYP1B1TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767170-B1 | NOVEL 4,6-DIARYLPYRIMIDINE DERIVATIVES AND SALTS THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2002-10-23 | — | — | EP | disclosed |
| US-5786355-A | COMPOUNDS FOR TREATMENT OF CANCER, RHEUMATISM, DIABETIC RETINOPATHY OR PSORIASIS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1998-07-28 | — | — | US | disclosed |
| EP-0767170-A1 | NOVEL 4,6-DIARYLPYRIMIDINE DERIVATIVES AND SALTS THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1997-04-09 | — | — | EP | disclosed |