Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 2/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7462375 | 1.00 | SCN1A (0.41) | SCN1ASCN2ASCN3ACYP3A4CYP2D6 | |
| SCHEMBL7462298 | 0.91 | SCN1A (0.38) | SCN1ASCN2ASCN3APOLB | |
| SCHEMBL7462283 | 0.91 | SCN1A (0.38) | SCN1ASCN2ASCN3APOLB | |
| SCHEMBL3231146 | 0.82 | SMN1; SMN2 (0.49) | CYP3A4CYP2D6KCNH2POLBTSHR | |
| SCHEMBL27522848 | 0.81 | BCHE (0.51) | CYP3A4CYP2D6KCNH2POLBTSHR | |
| SCHEMBL20143210 | 0.80 | SMN1; SMN2 (0.53) | SCN1ASCN2ASCN3ACYP3A4CYP2D6 | |
| SCHEMBL9044282 | 0.80 | SMN1; SMN2 (0.53) | SCN1ASCN2ASCN3ACYP3A4CYP2D6 | |
| SCHEMBL7464291 | 0.80 | LMNA (0.34) | SCN1ASCN2ASCN3ACYP3A4CYP2D6 | |
| SCHEMBL7465335 | 0.80 | LMNA (0.34) | SCN1ASCN2ASCN3ACYP3A4CYP2D6 | |
| SCHEMBL7464282 | 0.80 | LMNA (0.34) | SCN1ASCN2ASCN3ACYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098894-B1 | FKBP INHIBITORS | PFIZER LTD (GB) | 2002-10-02 | — | — | EP | disclosed |