Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 13/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MARS1 | P56192 | 1/20 | 0.54 |
| ▸ | PPP1CA | P62136 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463244 | 0.83 | RPA1 (0.76) | RPA1SMN1; SMN2MARS1PPP1CAL3MBTL1 | |
| SCHEMBL7872744 | 0.82 | RIPK2 (0.43) | RPA1 | |
| SCHEMBL9204658 | 0.78 | KMT2A (0.72) | RPA1SMN1; SMN2MARS1PPP1CAL3MBTL1 | |
| SCHEMBL9204760 | 0.78 | KMT2A (0.72) | RPA1SMN1; SMN2MARS1PPP1CAL3MBTL1 | |
| SCHEMBL9201599 | 0.77 | RPA1 (0.58) | RPA1SMN1; SMN2PPP1CAL3MBTL1MEN1 | |
| SCHEMBL8638380 | 0.77 | RPA1 (0.55) | RPA1SMN1; SMN2PPP1CAL3MBTL1MEN1 | |
| SCHEMBL8641975 | 0.76 | RPA1 (0.67) | RPA1SMN1; SMN2PPP1CAL3MBTL1MEN1 | |
| SCHEMBL3863671 | 0.76 | SMN1; SMN2 (0.69) | RPA1SMN1; SMN2PPP1CAL3MBTL1MEN1 | |
| SCHEMBL7874517 | 0.75 | RPA1 (0.43) | RPA1SMN1; SMN2MEN1KMT2AATM | |
| SCHEMBL3863481 | 0.74 | MALT1 (0.66) | RPA1SMN1; SMN2PPP1CAL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018741-A2 | PYRAZOLE COMPOUNDS AS COX-2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-04-06 | — | — | WO | disclosed |