Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985762 | 0.88 | TSHR (0.57) | SMN1; SMN2TSHRALDH1A1GAAMAPK1 | |
| SCHEMBL30736569 | 0.85 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1GAAKMT2AKDM4E | |
| SCHEMBL954897 | 0.85 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1GAAKMT2AKDM4E | |
| SCHEMBL5427764 | 0.84 | ALDH1A1 (0.53) | SMN1; SMN2TSHRALDH1A1GAAMAPK1 | |
| SCHEMBL29165513 | 0.84 | TSHR (0.50) | SMN1; SMN2TSHRALDH1A1KMT2AKDM4E | |
| SCHEMBL9806499 | 0.83 | ALDH1A1 (0.47) | SMN1; SMN2TSHRALDH1A1GAAMAPK1 | |
| SCHEMBL2666954 | 0.80 | KDM4E (0.58) | SMN1; SMN2ALDH1A1GAAMAPK1KMT2A | |
| SCHEMBL29165515 | 0.80 | TSHR (0.49) | SMN1; SMN2TSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL1126945 | 0.78 | TSHR (0.53) | SMN1; SMN2TSHRALDH1A1MAPK1KMT2A | |
| SCHEMBL15689544 | 0.77 | CTSD (0.65) | SMN1; SMN2TSHRALDH1A1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888340-B1 | 4-(BENZO-1,3-DIOXOLYL)-PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | ABBOTT LAB (US) | 2002-07-17 | — | — | EP | disclosed |
| US-6124341-A | A DRUG FOR TREATING HYPERTENSION, CONGESTIVE HEART FAILURE, RESTENOSIS FOLLOWING ARTERIAL INJURY, CEREBRAL OR MYOCARDIAL ISCHEMIA OR ATHEROSCLEROSIS; VASODILUTOR | ABBOTT LABORATORIES (US) | 2000-09-26 | — | — | US | disclosed |
| EP-0991620-A1 | PYRROLIDINE CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | Abbott Laboratories (US) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998057933-A1 | PYRROLIDINE CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | ABBOTT LABORATORIES (US) | 1998-12-23 | — | — | WO | disclosed |