Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 8/20 | 0.56 |
| ▸ | ZAP70 | P43403 | 8/20 | 0.56 |
| ▸ | SYK | P43405 | 8/20 | 0.56 |
| ▸ | CDK2 | P24941 | 5/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464447 | 0.89 | PIK3CA (0.62) | SRCZAP70SYKCDK2CDK4 | |
| SCHEMBL7469251 | 0.82 | IKBKB (0.52) | SRCCDK2CDK4ABL1BCR | |
| SCHEMBL7469678 | 0.79 | SYK (0.56) | SYKCDK2CDK4PIK3CAPIK3CG | |
| SCHEMBL7471151 | 0.78 | PIK3CA (0.60) | CDK2PIK3CAPIK3CGKDM4EALDH1A1 | |
| SCHEMBL7465974 | 0.78 | GAA (0.47) | SRCZAP70SYKCDK2ALDH1A1 | |
| SCHEMBL7471212 | 0.78 | CDK5 (0.47) | SRCZAP70SYKCDK2CDK4 | |
| SCHEMBL14088970 | 0.77 | KDM4E (0.53) | KDM4EALDH1A1GLAGAAMAPT | |
| SCHEMBL7464938 | 0.77 | KDR (0.64) | SRCZAP70SYKCDK2CDK4 | |
| SCHEMBL7471251 | 0.76 | JAK2 (0.66) | ABL1BCRALDH1A1MAPT | |
| SCHEMBL7471347 | 0.75 | SRC (0.64) | SRCZAP70SYKCDK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |