Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.64 |
| ▸ | SYK | P43405 | 17/20 | 0.60 |
| ▸ | SRC | P12931 | 3/20 | 0.59 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.59 |
| ▸ | CDK2 | P24941 | 3/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | BCR | P11274 | 1/20 | 0.56 |
| ▸ | PRKCA | P17252 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471678 | 0.89 | ABL1 (0.64) | SYKSRCZAP70CDK2ABL1 | |
| SCHEMBL7461176 | 0.83 | SYK (0.62) | SYKABL1BCRPRKCA | |
| SCHEMBL7470857 | 0.83 | ABL1 (0.63) | SYKCDK2ABL1BCRPRKCA | |
| SCHEMBL2823600 | 0.81 | KCNN1 (0.62) | KDRSYKABL1BCRPRKCA | |
| SCHEMBL4894535 | 0.81 | SYK (0.62) | SYKCDK2ABL1BCRPRKCA | |
| SCHEMBL4903508 | 0.80 | ABL1 (0.67) | SYKSRCCDK2ABL1BCR | |
| SCHEMBL6980729 | 0.80 | IGF1R (0.68) | KDRSYKZAP70CDK2PRKCA | |
| Hydrochloric Acid SCHEMBL10769093 | 0.79 | SYK (0.60) | SYKCDK2ABL1BCRPRKCA | |
| SCHEMBL7469712 | 0.79 | SYK (0.49) | SYKSRCABL1BCRPRKCA | |
| SCHEMBL7477243 | 0.79 | SYK (0.62) | SYKSRCABL1BCRPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |
| US-4876252-A | ADMINISTERING ANTIASTHMATIC OR ANTIALLERGEN | AMERICAN CYANAMID COMPANY (US) | 1989-10-24 | — | — | US | disclosed |