Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | BCR | P11274 | 1/20 | 0.62 |
| ▸ | CDK2 | P24941 | 3/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.60 |
| ▸ | SYK | P43405 | 1/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.58 |
| ▸ | CDK1 | P06493 | 2/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463567 | 0.89 | SRC (0.56) | PIK3CAPIK3CGABL1BCRCDK2 | |
| SCHEMBL7471212 | 0.84 | CDK5 (0.47) | PIK3CAPIK3CGABL1BCRCDK2 | |
| SCHEMBL7471678 | 0.78 | ABL1 (0.64) | PIK3CAPIK3CGABL1BCRCDK2 | |
| SCHEMBL7467324 | 0.78 | ABL1 (0.76) | PIK3CAPIK3CGABL1BCRCDK2 | |
| SCHEMBL2322043 | 0.77 | PIK3CG (0.70) | PIK3CAPIK3CGABL1BCRCDK2 | |
| SCHEMBL7465887 | 0.77 | ABL1 (0.70) | PIK3CAPIK3CGABL1BCRCDK2 | |
| SCHEMBL7473582 | 0.77 | CDK2 (0.65) | PIK3CAPIK3CGABL1BCRCDK2 | |
| SCHEMBL2331086 | 0.77 | PIK3CG (0.70) | PIK3CAPIK3CGABL1BCRCDK2 | |
| SCHEMBL14088797 | 0.77 | PIK3CA (0.62) | PIK3CAPIK3CGABL1BCRCDK2 | |
| SCHEMBL7465567 | 0.77 | PIK3CA (0.62) | PIK3CAPIK3CGABL1BCRCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | claimed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | claimed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | claimed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | claimed |