Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476727 | 0.99 | SIGMAR1 (0.52) | SIGMAR1DRD2DRD4HTR1APPARG | |
| SCHEMBL7477190 | 0.90 | DRD2 (0.42) | SIGMAR1DRD2DRD4HTR1ATMEM97 | |
| SCHEMBL7473374 | 0.86 | SIGMAR1 (0.46) | SIGMAR1DRD2HTR1APPARGPPARA | |
| SCHEMBL6171250 | 0.81 | SIGMAR1 (0.52) | SIGMAR1DRD2DRD4HTR1AHTR2A | |
| Piclozotan SCHEMBL29379540 | 0.81 | SIGMAR1 (0.54) | SIGMAR1DRD2DRD4HTR1AHTR2A | |
| Piclozotan SCHEMBL30249060 | 0.81 | SIGMAR1 (0.54) | SIGMAR1DRD2DRD4HTR1AHTR2A | |
| Piclozotan SCHEMBL562627 | 0.81 | SIGMAR1 (0.54) | SIGMAR1DRD2DRD4HTR1AHTR2A | |
| SCHEMBL7472426 | 0.81 | SIGMAR1 (0.51) | SIGMAR1DRD2 | |
| SCHEMBL7471246 | 0.81 | SIGMAR1 (0.53) | SIGMAR1DRD2DRD4HTR1AHTR2A | |
| Piclozotan SCHEMBL3675097 | 0.80 | SIGMAR1 (0.52) | SIGMAR1DRD2DRD4HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755930-B1 | BENZOXAZEPINE DERIVATIVES, SALTS THEREOF, AND DRUGS CONTAINING THE SAME | SUNTORY LTD (JP) | 2002-07-31 | — | — | EP | disclosed |
| US-6337397-B1 | A BENZOXAZEPINE DERIVATIVE FOR TREATMENT OF ANXIETY NEUROSIS, PHOBIAS, OBSESSIVE-COMPULSIVE DISORDERS, SCHIZOPHRENIA, POST-CARDIAC TRAUMA STRESS DISORDERS, DEPRESSION DISORDERS, PSYCHOSOMATIC DISORDERS AND OTHER PSYCHONEUROTIC DISORDERS, | SUNTORY LIMITED (JP) | 2002-01-08 | — | — | US | disclosed |
| US-6187769-B1 | Benzoxazepine derivatives and their salts and medicaments containing the same | SUNTORY LIMITED (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0755930-A1 | BENZOXAZEPINE DERIVATIVES, SALTS THEREOF, AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |