Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472531 | 0.90 | SIGMAR1 (0.42) | SIGMAR1PPARGPPARAHTR1AHTR6 | |
| SCHEMBL7476727 | 0.87 | SIGMAR1 (0.52) | SIGMAR1PPARGPPARAHTR1ADRD2 | |
| SCHEMBL7476391 | 0.87 | PARP1 (0.40) | SIGMAR1HTR1AHTR6PARP1KDM4E | |
| SCHEMBL7464006 | 0.86 | SIGMAR1 (0.53) | SIGMAR1PPARGPPARAHTR1AHTR6 | |
| SCHEMBL7466343 | 0.86 | SIGMAR1 (0.37) | SIGMAR1HTR1ADRD2 | |
| SCHEMBL7467271 | 0.84 | SIGMAR1 (0.48) | SIGMAR1PPARGPPARAHTR1ADRD2 | |
| SCHEMBL7477921 | 0.81 | DRD2 (0.50) | HTR1ADRD2 | |
| SCHEMBL7468538 | 0.81 | HTR1A (0.55) | SIGMAR1HTR1A | |
| SCHEMBL7477641 | 0.79 | DRD2 (0.48) | HTR1AKDM4EALDH1A1DRD2 | |
| SCHEMBL7470642 | 0.79 | SIGMAR1 (0.35) | SIGMAR1HTR1AHTR6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755930-B1 | BENZOXAZEPINE DERIVATIVES, SALTS THEREOF, AND DRUGS CONTAINING THE SAME | SUNTORY LTD (JP) | 2002-07-31 | — | — | EP | disclosed |
| US-6337397-B1 | A BENZOXAZEPINE DERIVATIVE FOR TREATMENT OF ANXIETY NEUROSIS, PHOBIAS, OBSESSIVE-COMPULSIVE DISORDERS, SCHIZOPHRENIA, POST-CARDIAC TRAUMA STRESS DISORDERS, DEPRESSION DISORDERS, PSYCHOSOMATIC DISORDERS AND OTHER PSYCHONEUROTIC DISORDERS, | SUNTORY LIMITED (JP) | 2002-01-08 | — | — | US | disclosed |
| US-6187769-B1 | Benzoxazepine derivatives and their salts and medicaments containing the same | SUNTORY LIMITED (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0755930-A1 | BENZOXAZEPINE DERIVATIVES, SALTS THEREOF, AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |