Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 6/20 | 0.83 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.83 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.83 |
| ▸ | ABL1 | P00519 | 4/20 | 0.68 |
| ▸ | BCR | P11274 | 4/20 | 0.68 |
| ▸ | PRKCA | P17252 | 2/20 | 0.68 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.67 |
| ▸ | SRC | P12931 | 1/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.66 |
| ▸ | MTOR | P42345 | 1/20 | 0.64 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.64 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 3/20 | 0.58 |
| ▸ | GSK3B | P49841 | 3/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | CDK4 | P11802 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27116598 | 0.90 | PIK3CG (0.83) | PIK3CGPIK3CAPIK3CBCDK5EGFR | |
| SCHEMBL7474612 | 0.88 | PIK3CG (0.76) | PIK3CGPIK3CAPIK3CBABL1BCR | |
| SCHEMBL27115896 | 0.88 | PIK3CG (0.76) | PIK3CGPIK3CAPIK3CBABL1BCR | |
| SCHEMBL8489648 | 0.88 | PIK3CG (0.76) | PIK3CGPIK3CAPIK3CBABL1BCR | |
| SCHEMBL2324992 | 0.88 | PIK3CG (0.76) | PIK3CGPIK3CAPIK3CBABL1BCR | |
| SCHEMBL5999205 | 0.86 | PIK3CG (0.77) | PIK3CGPIK3CAPIK3CBABL1BCR | |
| SCHEMBL8489646 | 0.85 | PIK3CG (0.76) | PIK3CGPIK3CAPIK3CBABL1BCR | |
| SCHEMBL7466208 | 0.85 | PIK3CG (0.72) | PIK3CGPIK3CAPIK3CBABL1BCR | |
| SCHEMBL2942460 | 0.85 | PIK3CG (0.76) | PIK3CGPIK3CAPIK3CBCDK5EGFR | |
| SCHEMBL12764225 | 0.84 | PIK3CG (0.74) | PIK3CGPIK3CAPIK3CBABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |