Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 6/20 | 0.77 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.77 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.77 |
| ▸ | MTOR | P42345 | 1/20 | 0.63 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.55 |
| ▸ | CDK2 | P24941 | 3/20 | 0.55 |
| ▸ | GSK3B | P49841 | 3/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.55 |
| ▸ | PRKCA | P17252 | 2/20 | 0.53 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27116598 | 0.89 | PIK3CG (0.83) | PIK3CGPIK3CAPIK3CBMTORSMG1 | |
| SCHEMBL8489648 | 0.87 | PIK3CG (0.76) | PIK3CGPIK3CAPIK3CBMTORSMG1 | |
| SCHEMBL2324992 | 0.87 | PIK3CG (0.76) | PIK3CGPIK3CAPIK3CBMTORSMG1 | |
| SCHEMBL27115896 | 0.87 | PIK3CG (0.76) | PIK3CGPIK3CAPIK3CBMTORSMG1 | |
| SCHEMBL7464195 | 0.86 | PIK3CG (0.83) | PIK3CGPIK3CAPIK3CBMTORSMG1 | |
| SCHEMBL27116597 | 0.86 | PIK3CG (0.73) | PIK3CGPIK3CAPIK3CBEGFRCDK5 | |
| SCHEMBL2942460 | 0.84 | PIK3CG (0.76) | PIK3CGPIK3CAPIK3CBMTORSMG1 | |
| SCHEMBL7813342 | 0.84 | PIK3CA (0.67) | PIK3CGPIK3CAPIK3CBMTORSMG1 | |
| SCHEMBL2327107 | 0.84 | FGFR2 (0.56) | PIK3CGPIK3CAPIK3CBMTORSMG1 | |
| SCHEMBL3513778 | 0.84 | CAMK2D (0.73) | PIK3CGPIK3CAPIK3CBMTORSMG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7151096-B2 | Cyclic compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2006-12-19 | — | — | US | disclosed |
| US-20040235841-A1 | Cyclic compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2004-11-25 | — | — | US | disclosed |
| WO-2004078682-A2 | CYCLIC COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235841-A1 | Cyclic compounds and compositions as protein kinase inhibitors | CDK2, CDK5, CDK1 | PIK3CG 242/4885PIK3CA 174/4885PIK3CB 179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.