Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALPL | P05186 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | GFER | P55789 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22204510 | 0.86 | KMT2A (0.61) | KMT2AMEN1HPGDALDH1A1RAB9A | |
| SCHEMBL29867812 | 0.86 | KMT2A (0.61) | KMT2AMEN1HPGDALDH1A1RAB9A | |
| SCHEMBL7461294 | 0.82 | KMT2A (0.54) | KMT2AMEN1HPGDALDH1A1RAB9A | |
| SCHEMBL11544944 | 0.81 | ALDH1A1 (0.53) | KMT2AMEN1HPGDALDH1A1RAB9A | |
| SCHEMBL7457669 | 0.81 | KMT2A (0.62) | KMT2AMEN1HPGDALDH1A1RAB9A | |
| SCHEMBL10550224 | 0.78 | KMT2A (0.59) | KMT2AMEN1HPGDALDH1A1RAB9A | |
| SCHEMBL29867786 | 0.78 | KMT2A (0.62) | KMT2AMEN1HPGDALDH1A1RAB9A | |
| SCHEMBL22204506 | 0.78 | KMT2A (0.62) | KMT2AMEN1HPGDALDH1A1RAB9A | |
| SCHEMBL18304782 | 0.76 | KMT2A (0.54) | KMT2AMEN1HPGDALDH1A1RAB9A | |
| SCHEMBL29867643 | 0.76 | KMT2A (0.54) | KMT2AMEN1HPGDALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |