Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470149 | 0.93 | SYK (0.36) | SYK | |
| SCHEMBL7470446 | 0.90 | SYK (0.35) | SYKHRH4 | |
| SCHEMBL7461868 | 0.90 | ABCB1 (0.32) | ABCB1 | |
| SCHEMBL7467851 | 0.89 | SYK (0.36) | SYKABCB1 | |
| SCHEMBL7464789 | 0.88 | KDM4E (0.36) | SYKABCB1HRH4 | |
| SCHEMBL7473667 | 0.85 | PYGL (0.33) | ABCB1 | |
| SCHEMBL7461465 | 0.84 | ABCB1 (0.33) | SYKABCB1HRH4 | |
| Hydrochloric Acid SCHEMBL7466838 | 0.84 | SYK (0.36) | SYKABCB1 | |
| SCHEMBL7468511 | 0.83 | HRH4 (0.36) | SYKABCB1HRH4 | |
| Hydrochloric Acid SCHEMBL7462551 | 0.83 | FLT3 (0.37) | SYKABCB1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656360-B1 | TRIFLUOROMETHYLPYRROLOINDOLE CARBOXYLIC ESTER DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | KYORIN SEIYAKU KK (JP) | 2002-11-20 | — | — | EP | disclosed |
| US-5629430-A | ANTICARCINOGENIC AGENTS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1997-05-13 | — | — | US | disclosed |
| EP-0656360-A1 | TRIFLUOROMETHYLPYRROLOINDOLE CARBOXYLIC ESTER DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1995-06-07 | — | — | EP | disclosed |