Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.69 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.69 |
| ▸ | PLK1 | P53350 | 1/20 | 0.59 |
| ▸ | CCR1 | P32246 | 1/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10273916 | 1.00 | TAS1R3 (0.69) | TAS1R3TAS1R1PLK1CCR1ADAM17 | |
| SCHEMBL4165636 | 0.83 | TAS1R3 (0.79) | TAS1R3TAS1R1PLK1CCR1ADAM17 | |
| SCHEMBL27497061 | 0.82 | TAS1R3 (0.67) | TAS1R3TAS1R1PLK1CCR1ADAM17 | |
| SCHEMBL7472151 | 0.82 | CAPN1 (0.58) | CCR1ADAM17HDAC1HDAC2 | |
| SCHEMBL4203545 | 0.81 | TAS1R3 (1.00) | TAS1R3TAS1R1PLK1CCR1ADAM17 | |
| SCHEMBL4203543 | 0.81 | TAS1R3 (1.00) | TAS1R3TAS1R1PLK1CCR1ADAM17 | |
| SCHEMBL17514270 | 0.80 | TAS1R3 (0.84) | TAS1R3TAS1R1PLK1CCR1ADAM17 | |
| SCHEMBL31425751 | 0.79 | PLK1 (0.66) | TAS1R3TAS1R1PLK1CCR1ADAM17 | |
| SCHEMBL30025133 | 0.79 | PLK1 (0.66) | TAS1R3TAS1R1PLK1CCR1ADAM17 | |
| SCHEMBL17514250 | 0.77 | TAS1R3 (0.69) | TAS1R3TAS1R1PLK1CCR1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020065230-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2002-05-30 | — | — | US | claimed |
| EP-0983228-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-08-07 | — | — | EP | disclosed |
| US-20020065230-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2002-05-30 | — | — | US | disclosed |
| EP-0983228-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998050342-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020065230-A1 | Protease inhibitors | PRSS1, DNPEP, CTSZ | TAS1R3 2410/4885TAS1R1 2189/4885PLK1 1829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.