Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 2/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5987754 | 0.84 | HTR2C (0.43) | HTR2CMAPTCASP3NOTUM | |
| SCHEMBL1928764 | 0.77 | MEN1 (0.44) | CES2MAPTNPSR1XBP1MEN1 | |
| SCHEMBL4995601 | 0.69 | IDO1 (0.33) | HTR2CCSNK2A1ALOX15 | |
| SCHEMBL6167848 | 0.68 | HTR2C (0.31) | HTR2C | |
| SCHEMBL2001354 | 0.68 | CES2 (0.55) | CES2MAPTNPSR1TMPRSS4MEN1 | |
| SCHEMBL25193520 | 0.66 | NLRP3 (0.38) | XDHSLC22A12CASP3TSHR | |
| SCHEMBL28171587 | 0.66 | HTR2C (0.43) | HTR2CMAPT | |
| SCHEMBL29632676 | 0.65 | MAPT (0.53) | CES2MAPTNPSR1XBP1MEN1 | |
| SCHEMBL496276 | 0.65 | MAPT (0.53) | CES2MAPTNPSR1XBP1MEN1 | |
| SCHEMBL290533 | 0.65 | CES2 (0.50) | CES2MAPTNPSR1XBP1TAS2R14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204658-A1 | BENZOFURYLPIPERAZINE SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009123-A1 | BENZOFURYLPIPERAZINE SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |