Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 3/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 8/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467700 | 1.00 | MMP2 (0.41) | MMP2MMP9CA1CA2FOLH1 | |
| SCHEMBL7463704 | 0.91 | MAPT (0.37) | CA1CA2RORC | |
| SCHEMBL7468900 | 0.91 | MAPT (0.37) | CA1CA2RORC | |
| SCHEMBL7470889 | 0.88 | NPSR1 (0.35) | CA1CA2 | |
| SCHEMBL7475987 | 0.88 | NPSR1 (0.35) | CA1CA2 | |
| Trifluoroacetic Acid SCHEMBL8742783 | 0.86 | TDP1 (0.36) | CA1CA2 | |
| SCHEMBL8593348 | 0.83 | NPSR1 (0.39) | — | |
| SCHEMBL8593351 | 0.83 | NPSR1 (0.39) | — | |
| SCHEMBL8592050 | 0.80 | CA1 (0.38) | MMP2MMP9CA1CA2FOLH1 | |
| SCHEMBL7472874 | 0.79 | PTPN11 (0.38) | MMP2MMP9FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687251-B1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI SYNTHELABO (FR) | 2002-02-27 | — | — | EP | disclosed |
| US-5594023-A | 1,3-dihydroindol-2-one derivatives substituted in the 3-position by a nitrogen-containing group, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1997-01-14 | — | — | US | disclosed |
| WO-1995018105-A1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI (FR) | 1995-07-06 | — | — | WO | disclosed |