Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 16/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465134 | 0.94 | PTPN11 (0.37) | PTPN11MMP2MMP9 | |
| SCHEMBL7467895 | 0.79 | PTPN11 (0.41) | PTPN11ADRB2ADRB1ADRB3 | |
| SCHEMBL7464677 | 0.79 | MMP2 (0.41) | MMP2MMP9FOLH1 | |
| SCHEMBL7467700 | 0.79 | MMP2 (0.41) | MMP2MMP9FOLH1 | |
| Trifluoroacetic Acid SCHEMBL8590187 | 0.76 | PTPN11 (0.39) | PTPN11ADRB2ADRB1ADRB3 | |
| SCHEMBL7470458 | 0.76 | PTPN11 (0.40) | PTPN11 | |
| SCHEMBL8589876 | 0.75 | PTPN11 (0.36) | PTPN11MMP2MMP9ADRB2ADRB1 | |
| SCHEMBL7466955 | 0.74 | PTPN11 (0.37) | PTPN11 | |
| SCHEMBL7466247 | 0.74 | PTPN11 (0.39) | PTPN11 | |
| Trifluoroacetic Acid SCHEMBL8742747 | 0.73 | PTPN11 (0.37) | PTPN11ADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687251-B1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI SYNTHELABO (FR) | 2002-02-27 | — | — | EP | disclosed |
| US-5594023-A | 1,3-dihydroindol-2-one derivatives substituted in the 3-position by a nitrogen-containing group, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1997-01-14 | — | — | US | disclosed |
| WO-1995018105-A1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI (FR) | 1995-07-06 | — | — | WO | disclosed |