Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.58 |
| ▸ | HTR1A | P08908 | 9/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.58 |
| ▸ | HTR7 | P34969 | 3/20 | 0.58 |
| ▸ | HTR6 | P50406 | 3/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466385 | 0.89 | DRD2 (0.62) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL7463051 | 0.86 | HTR1A (0.64) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL7534561 | 0.79 | HTR1A (0.70) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL7533659 | 0.79 | HTR1A (0.62) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL15064476 | 0.79 | SLC6A4 (0.69) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL7458916 | 0.78 | HTR1A (0.62) | DRD2HTR1ASLC6A4HTR6HTR2A | |
| SCHEMBL791945 | 0.77 | DRD2 (0.70) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL15064308 | 0.77 | DRD2 (0.89) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL7669482 | 0.77 | HTR1A (0.61) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL790948 | 0.76 | DRD2 (0.72) | DRD2HTR1ASLC6A4HTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073651-B1 | INDOLYL DERIVATIVES AS SEROTONERGIC AGENTS | WYETH CORP (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6066637-A | NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANT | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-05-23 | — | — | US | disclosed |