Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470738 | 1.00 | MMP2 (0.46) | MMP2MMP9CA1CA2FOLH1 | |
| SCHEMBL7476845 | 0.88 | MMP2 (0.42) | MMP2MMP9FOLH1MEN1KMT2A | |
| SCHEMBL9264893 | 0.87 | SIRT2 (0.46) | MMP2MMP9CA1CA2SIRT2 | |
| SCHEMBL7474973 | 0.86 | MAPT (0.40) | MMP2MMP9FOLH1MEN1KMT2A | |
| SCHEMBL9288393 | 0.86 | MAPT (0.40) | MMP2MMP9FOLH1MEN1KMT2A | |
| SCHEMBL7464677 | 0.75 | MMP2 (0.41) | MMP2MMP9CA1CA2FOLH1 | |
| SCHEMBL7473970 | 0.75 | ADCY8 (0.42) | MEN1KMT2A | |
| SCHEMBL29549390 | 0.74 | CA1 (0.63) | MMP2MMP9CA1CA2FOLH1 | |
| SCHEMBL25932584 | 0.74 | CA1 (0.63) | MMP2MMP9CA1CA2FOLH1 | |
| SCHEMBL5066026 | 0.74 | CBX7 (0.35) | KMT2ATGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687251-B1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI SYNTHELABO (FR) | 2002-02-27 | — | — | EP | disclosed |
| US-5594023-A | 1,3-dihydroindol-2-one derivatives substituted in the 3-position by a nitrogen-containing group, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1997-01-14 | — | — | US | disclosed |
| WO-1995018105-A1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI (FR) | 1995-07-06 | — | — | WO | disclosed |