Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.56 |
| ▸ | HTR2B | P41595 | 2/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.56 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.56 |
| ▸ | NAE1 | Q13564 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463279 | 0.94 | AGTR2 (0.50) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL7467950 | 0.94 | AGTR2 (0.56) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL2773417 | 0.92 | AGTR2 (0.57) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL7467345 | 0.89 | ABCB11 (0.43) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL7466355 | 0.88 | ABCB11 (0.43) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL7470556 | 0.88 | ABCB11 (0.43) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL683298 | 0.87 | AGTR2 (0.62) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL7467056 | 0.87 | ABCB11 (0.42) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL7467167 | 0.87 | ABCB11 (0.42) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL4610115 | 0.86 | AGTR1 (0.51) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720982-B1 | Benzimidazole derivatives, their production and use and use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-11-13 | — | — | EP | claimed |