Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 16/20 | 0.45 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.40 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5562661 | 0.88 | KCNQ4 (0.42) | KCNQ4KCNQ5 | |
| SCHEMBL7459594 | 0.88 | KCNQ4 (0.40) | VCPKCNQ4KCNQ5 | |
| SCHEMBL7703613 | 0.87 | VCP (0.47) | VCP | |
| SCHEMBL5556325 | 0.86 | KCNQ4 (0.41) | KCNQ4KCNQ5 | |
| SCHEMBL7462019 | 0.85 | VCP (0.41) | VCP | |
| SCHEMBL7700580 | 0.84 | VCP (0.40) | VCPKCNQ4KCNQ5 | |
| SCHEMBL7704382 | 0.82 | VCP (0.37) | VCPKCNQ4KCNQ5 | |
| SCHEMBL5558039 | 0.82 | NPC1 (0.39) | — | |
| SCHEMBL5868878 | 0.82 | KCNQ4 (0.44) | KCNQ4KCNQ5 | |
| SCHEMBL7459618 | 0.82 | VCP (0.54) | VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224175-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029012-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |