Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 10/20 | 0.73 |
| ▸ | PIM2 | Q9P1W9 | 10/20 | 0.73 |
| ▸ | IGF1R | P08069 | 2/20 | 0.73 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.63 |
| ▸ | CISD1 | Q9NZ45 | 4/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 1/20 | 0.63 |
| ▸ | GSK3B | P49841 | 1/20 | 0.63 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.62 |
| ▸ | TTR | P02766 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | MYC | P01106 | 1/20 | 0.58 |
| ▸ | MAX | P61244 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465302 | 1.00 | PIM1 (0.73) | PIM1PIM2IGF1RAKR1B1CISD1 | |
| SCHEMBL17147367 | 0.86 | HPGD (0.73) | PIM1PIM2IGF1RAKR1B1CISD1 | |
| SCHEMBL2539573 | 0.85 | PIM1 (1.00) | PIM1PIM2IGF1RAKR1B1CISD1 | |
| SCHEMBL2539569 | 0.85 | PIM1 (1.00) | PIM1PIM2IGF1RAKR1B1CISD1 | |
| SCHEMBL2539566 | 0.85 | PIM1 (1.00) | PIM1PIM2IGF1RAKR1B1CISD1 | |
| SCHEMBL7465312 | 0.83 | CSNK2A2 (0.51) | PIM1PIM2IGF1RAKR1B1CISD1 | |
| SCHEMBL2539676 | 0.81 | PIM1 (1.00) | PIM1PIM2IGF1RAKR1B1CISD1 | |
| SCHEMBL2539679 | 0.81 | PIM1 (1.00) | PIM1PIM2IGF1RAKR1B1CISD1 | |
| SCHEMBL2539680 | 0.81 | PIM1 (1.00) | PIM1PIM2IGF1RAKR1B1CISD1 | |
| SCHEMBL1581116 | 0.80 | MAOA (0.59) | PIM1PIM2IGF1RAKR1B1CISD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214305-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | Maxia Pharmaceuticals, Inc. (US) | 2002-06-19 | — | — | EP | claimed |
| WO-2001016123-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | MAXIA PHARMACEUTICALS, INC. (US) | 2001-03-08 | — | — | WO | claimed |