Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470843 | 0.78 | ALDH1A1 (0.38) | KDM4EALDH1A1MAPTHSD17B10ADORA2A | |
| SCHEMBL7807450 | 0.78 | TAAR1 (0.53) | KDM4EALDH1A1MAPK1MAPTHSD17B10 | |
| SCHEMBL7468150 | 0.77 | NPC1 (0.48) | KDM4EALDH1A1CYP19A1MAPK1MAPT | |
| Hydrochloric Acid SCHEMBL7807700 | 0.76 | TAAR1 (0.52) | KDM4EALDH1A1MAPK1MAPTHSD17B10 | |
| SCHEMBL7476653 | 0.75 | ABL1 (0.48) | ALDH1A1CYP19A1MAPTADORA2AGAA | |
| SCHEMBL7086205 | 0.74 | KDM1A (0.49) | KDM4EALDH1A1MAPK1MAPTHSD17B10 | |
| SCHEMBL30792364 | 0.74 | KDM1A (0.49) | KDM4EALDH1A1MAPK1MAPTHSD17B10 | |
| SCHEMBL30921140 | 0.73 | HSP90AA1 (0.57) | CYP19A1MAPTMEN1 | |
| SCHEMBL7471145 | 0.73 | HSP90AA1 (0.57) | CYP19A1MAPTMEN1 | |
| SCHEMBL7468872 | 0.73 | KDM4E (0.57) | KDM4EALDH1A1CYP19A1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |