Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1822088 | 0.77 | KDM4E (0.61) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL33847 | 0.77 | KCNH2 (0.53) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL7476653 | 0.77 | ABL1 (0.48) | ALDH1A1NPC1MAPTKMT2ACYP19A1 | |
| SCHEMBL7476570 | 0.77 | KDM4E (0.64) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL7465490 | 0.76 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL7468150 | 0.75 | NPC1 (0.48) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| Hydrochloric Acid SCHEMBL6261430 | 0.75 | KCNH2 (0.52) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL7467076 | 0.75 | KCNH2 (0.41) | NPC1 | |
| SCHEMBL623986 | 0.74 | ALDH1A1 (1.00) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL7465325 | 0.73 | KDM4E (0.52) | KDM4EALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |