Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.52 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6114965 | 0.99 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3ABHD6MGLL | |
| SCHEMBL30758633 | 0.92 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3ABHD6MGLL | |
| SCHEMBL20490844 | 0.92 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3ABHD6MGLL | |
| Trifluoroacetic Acid SCHEMBL20983827 | 0.81 | ABHD6 (0.56) | SLC6A2SLC6A4SLC6A3ABHD6MGLL | |
| SCHEMBL24168412 | 0.81 | ABHD6 (0.55) | SLC6A2SLC6A4SLC6A3ABHD6MGLL | |
| SCHEMBL30334835 | 0.81 | ABHD6 (0.55) | SLC6A2SLC6A4SLC6A3ABHD6MGLL | |
| SCHEMBL1231217 | 0.76 | SLC6A4 (0.65) | SLC6A2SLC6A4SLC6A3TP53MEN1 | |
| SCHEMBL83664 | 0.76 | SLC6A4 (0.64) | SLC6A2SLC6A4SLC6A3TP53MEN1 | |
| Hydrochloric Acid SCHEMBL31093492 | 0.75 | SLC6A4 (0.63) | SLC6A2SLC6A4SLC6A3TP53MEN1 | |
| Hydrochloric Acid SCHEMBL69186 | 0.75 | SLC6A4 (0.63) | SLC6A2SLC6A4SLC6A3TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430012-B1 | 7-AZA-SPIRO[3.5]NONANE-7-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-11-05 | — | — | EP | disclosed |
| US-20130211087-A1 | 7-AZA-SPIRO[3,5]NONANE-7-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-08-15 | — | — | US | disclosed |
| US-8394787-B2 | 7-aza-spiro[3.5]nonane-7-carboxylate derivatives, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2013-03-12 | — | — | US | disclosed |
| US-20120129830-A1 | 7-AZA-SPIRO[3.5]NONANE-7-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-05-24 | — | — | US | disclosed |
| EP-2430012-A1 | 7-AZA-SPIRO[3.5]NONANE-7-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130945-A1 | 7-AZA-SPIRO[3.5]NONANE-7-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130211087-A1 | 7-AZA-SPIRO[3,5]NONANE-7-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | FAAH, FAAH2, ASAH1 | SLC6A2 3996/4885SLC6A4 3444/4885SLC6A3 4065/4885 |
| US-20120129830-A1 | 7-AZA-SPIRO[3.5]NONANE-7-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | HDAC7, NR3C2, EPOR | SLC6A2 2151/4885SLC6A4 3731/4885SLC6A3 1867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.