Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465335 | 1.00 | LMNA (0.34) | LMNAKCNK3POLBSCN1ASCN2A | |
| SCHEMBL7462283 | 0.88 | SCN1A (0.38) | LMNAKCNK3POLBSCN1ASCN2A | |
| SCHEMBL7462298 | 0.88 | SCN1A (0.38) | LMNAKCNK3POLBSCN1ASCN2A | |
| SCHEMBL7464291 | 0.86 | LMNA (0.34) | LMNAKCNK3POLBSCN1ASCN2A | |
| SCHEMBL7464282 | 0.86 | LMNA (0.34) | LMNAKCNK3POLBSCN1ASCN2A | |
| SCHEMBL7466710 | 0.84 | POLB (0.36) | LMNAKCNK3POLBSCN1ASCN2A | |
| SCHEMBL7462375 | 0.80 | SCN1A (0.41) | POLBSCN1ASCN2ASCN3ASMN1; SMN2 | |
| SCHEMBL7462371 | 0.80 | SCN1A (0.41) | POLBSCN1ASCN2ASCN3ASMN1; SMN2 | |
| SCHEMBL20143218 | 0.77 | LMNA (0.52) | LMNAKCNK3POLBSMN1; SMN2CYP3A4 | |
| SCHEMBL3969870 | 0.77 | LMNA (0.52) | LMNAKCNK3POLBSMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098894-B1 | FKBP INHIBITORS | PFIZER LTD (GB) | 2002-10-02 | — | — | EP | disclosed |
| EP-1098894-A1 | FKBP INHIBITORS | Pfizer Limited (GB) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000005231-A1 | FKBP INHIBITORS | PFIZER LIMITED (GB) | 2000-02-03 | — | — | WO | disclosed |