Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463152 | 0.92 | HTT (0.48) | MAPK1LMNAHTTPDGFRBMAPT | |
| SCHEMBL7467456 | 0.91 | EGFR (0.52) | ACHEMAPK1EGFRLMNAHTT | |
| SCHEMBL7465055 | 0.89 | HTR6 (0.55) | ACHEMAPK1EGFRAURKAFYN | |
| SCHEMBL7471194 | 0.88 | MAPK1 (0.48) | ACHEMAPK1EGFRAURKAFYN | |
| SCHEMBL7458966 | 0.87 | MAPK1 (0.47) | ACHEMAPK1EGFRAURKAFYN | |
| SCHEMBL7466158 | 0.86 | HTR6 (0.55) | MAPK1EGFRFYNSRCLMNA | |
| SCHEMBL7468943 | 0.84 | MAPK1 (0.46) | MAPK1EGFRFYNSRCLMNA | |
| SCHEMBL7467064 | 0.83 | HTR6 (0.52) | MAPK1EGFRFYNSRCLMNA | |
| SCHEMBL7463399 | 0.83 | PRKCQ (0.49) | MAPK1EGFRAURKAFYNSRC | |
| SCHEMBL7474097 | 0.81 | HRH4 (0.56) | HTTHTR6CDK1CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |