SCHEMBL7465471

SCHEMBL7465471

O=C(O)c1cc2cc(OCc3ccccc3)ccc2n1Cc1cc2c(cc1Cl)OCO2

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 1/20 0.54
LTB4R Q15722 1/20 0.52
LTB4R2 Q9NPC1 1/20 0.52
EDNRB P24530 4/20 0.50
EDNRA P25101 4/20 0.50
CCR2 P41597 8/20 0.49
ABCB11 O95342 2/20 0.48
MAOB P27338 1/20 0.48
S1PR1 P21453 1/20 0.48
PRKX P51817 1/20 0.48
ACVR1 Q04771 1/20 0.48
S1PR5 Q9H228 1/20 0.48
PLA2G4A P47712 1/20 0.47
F10 P00742 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7525789 0.93 ABCB11 (0.49) SRD5A2LTB4RLTB4R2EDNRBEDNRA
SCHEMBL7467129 0.92 CCR2 (0.54) SRD5A2EDNRBEDNRACCR2F10
SCHEMBL7455739 0.92 CCR2 (0.57) SRD5A2LTB4RLTB4R2EDNRBEDNRA
SCHEMBL7466282 0.90 CCR2 (0.58) SRD5A2LTB4RLTB4R2EDNRBEDNRA
SCHEMBL7472885 0.90 CCR2 (0.48) SRD5A2LTB4RLTB4R2EDNRBEDNRA
SCHEMBL7458022 0.89 CCR2 (0.52) SRD5A2LTB4RLTB4R2EDNRBEDNRA
SCHEMBL8385275 0.89 F10 (0.51) SRD5A2LTB4RLTB4R2EDNRBEDNRA
SCHEMBL7462084 0.89 S1PR1 (0.54) SRD5A2CCR2ABCB11S1PR1PRKX
SCHEMBL7466879 0.88 EDNRB (0.48) SRD5A2LTB4RLTB4R2EDNRBEDNRA
SCHEMBL7468637 0.88 CCR2 (0.47) SRD5A2LTB4RLTB4R2EDNRBEDNRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5955492-A Carboxylic acid indole inhibitors of chemokines SMITHKLINE BEECHAM CORPORATION (US) 1999-09-21 US claimed
EP-1242075-A4 INDOLE COMPOUNDS SMITHKLINE BEECHAM CORP (US) 2002-12-04 EP disclosed
EP-1242075-A2 INDOLE COMPOUNDS SmithKline Beecham Corporation (US) 2002-09-25 EP disclosed
EP-1021181-A4 CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES SMITHKLINE BEECHAM CORP (US) 2002-06-26 EP disclosed
WO-2001030752-A2 INDOLE COMPOUNDS FOR TREATING BACTERIAL INFECTIONS SMITHKLINE BEECHAM CORPORATION (US) 2001-05-03 WO disclosed
EP-1021181-A1 CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES SMITHKLINE BEECHAM CORPORATION (US) 2000-07-26 EP disclosed
US-5955492-A Carboxylic acid indole inhibitors of chemokines SMITHKLINE BEECHAM CORPORATION (US) 1999-09-21 US disclosed
WO-1997035572-A1 CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES SMITHKLINE BEECHAM CORPORATION (US) 1997-10-02 WO disclosed