Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 7/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465471 | 0.90 | SRD5A2 (0.54) | CCR2ABCB11SRD5A2S1PR5S1PR1 | |
| SCHEMBL7467129 | 0.88 | CCR2 (0.54) | CCR2SRD5A2EDNRBEDNRA | |
| SCHEMBL7137416 | 0.87 | CCR2 (0.45) | CCR2ABCB11SRD5A2S1PR5S1PR1 | |
| SCHEMBL7466632 | 0.87 | CCR2 (0.45) | CCR2ABCB11SRD5A2S1PR5S1PR1 | |
| SCHEMBL7246205 | 0.86 | CCR2 (0.49) | CCR2ABCB11SRD5A2PLA2G4ALTB4R | |
| SCHEMBL7525789 | 0.86 | ABCB11 (0.49) | CCR2ABCB11SRD5A2PLA2G4ALTB4R | |
| SCHEMBL7466282 | 0.86 | CCR2 (0.58) | CCR2ABCB11SRD5A2PLA2G4ALTB4R | |
| SCHEMBL7455739 | 0.85 | CCR2 (0.57) | CCR2ABCB11SRD5A2PLA2G4ALTB4R | |
| SCHEMBL7466879 | 0.85 | EDNRB (0.48) | CCR2ABCB11SRD5A2PLA2G4ALTB4R | |
| SCHEMBL7468637 | 0.85 | CCR2 (0.47) | CCR2ABCB11SRD5A2PLA2G4AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955492-A | Carboxylic acid indole inhibitors of chemokines | SMITHKLINE BEECHAM CORPORATION (US) | 1999-09-21 | — | — | US | claimed |
| EP-1242075-A4 | INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2002-12-04 | — | — | EP | disclosed |
| US-6486211-B1 | Indole compounds | SMITHKLINE BEECHAM CORPORATION | 2002-11-26 | — | — | US | disclosed |
| EP-1242075-A2 | INDOLE COMPOUNDS | SmithKline Beecham Corporation (US) | 2002-09-25 | — | — | EP | disclosed |
| EP-1021181-A4 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORP (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001030752-A2 | INDOLE COMPOUNDS FOR TREATING BACTERIAL INFECTIONS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-03 | — | — | WO | disclosed |
| EP-1021181-A1 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| US-5955492-A | Carboxylic acid indole inhibitors of chemokines | SMITHKLINE BEECHAM CORPORATION (US) | 1999-09-21 | — | — | US | disclosed |
| WO-1997035572-A1 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-02 | — | — | WO | disclosed |