Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | TLR4 | O00206 | 3/20 | 0.35 |
| ▸ | TLR2 | O60603 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473197 | 0.89 | HRH3 (0.33) | MAPTTLR4TLR2ALDH1A1KDM4E | |
| SCHEMBL7465483 | 0.82 | MAPT (0.35) | MAPTNPC1RAB9ANFKB1MAPK1 | |
| SCHEMBL7469316 | 0.81 | ADRB3 (0.42) | MAPTKMT2A | |
| SCHEMBL7460844 | 0.81 | TLR4 (0.32) | MAPTTLR4TLR2 | |
| SCHEMBL7468835 | 0.81 | TLR4 (0.32) | MAPTTLR4TLR2 | |
| SCHEMBL7470305 | 0.80 | MAPT (0.37) | MAPTNPC1RAB9AMAPK1ALDH1A1 | |
| SCHEMBL7470143 | 0.78 | MAPT (0.36) | MAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL7566557 | 0.78 | KMT2A (0.39) | MAPTNPC1RAB9ATLR2L3MBTL1 | |
| SCHEMBL7469205 | 0.76 | SMN1; SMN2 (0.39) | MAPTNPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL6301403 | 0.73 | HRH3 (0.45) | MAPTNPC1RAB9ANFKB1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214313-A2 | HETEROARYLOXY PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017989-A2 | HETEROARYLOXYPROPANOLAMINES AS BETA3-ADRENERGIC RECEPTOR AGONISTS | SANOFI-SYNTHELABO (FR) | 2001-03-15 | — | — | WO | disclosed |