Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.47 |
| ▸ | CES1 | P23141 | 3/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465792 | 1.00 | CES2 (0.47) | CES2CES1AKR1C3AKR1C2PTGS2 | |
| SCHEMBL6701791 | 0.89 | LMNA (0.43) | CES2AKR1C3AKR1C2LMNAMAPK1 | |
| SCHEMBL6675162 | 0.89 | LMNA (0.43) | CES2AKR1C3AKR1C2LMNAMAPK1 | |
| SCHEMBL6675154 | 0.89 | LMNA (0.43) | CES2AKR1C3AKR1C2LMNAMAPK1 | |
| SCHEMBL7563011 | 0.85 | CES2 (0.46) | CES2CES1AKR1C3AKR1C2PTGS2 | |
| SCHEMBL1669003 | 0.83 | CES2 (0.64) | CES2CES1LMNAMAPK1 | |
| SCHEMBL1669004 | 0.83 | CES2 (0.64) | CES2CES1LMNAMAPK1 | |
| SCHEMBL7676477 | 0.79 | AKR1C3 (0.41) | CES2CES1AKR1C3AKR1C2PTGS2 | |
| SCHEMBL23972302 | 0.76 | IDO1 (0.48) | CES2CES1AKR1C3AKR1C2LMNA | |
| SCHEMBL29723941 | 0.75 | CES2 (0.50) | CES2CES1LMNAMAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077701-A4 | ANTI-VIRAL COMPOUNDS | LILLY CO ELI (US) | 2002-03-20 | — | — | EP | disclosed |
| US-6358971-B1 | FOR INHIBITING THE GROWTH OF A PICORNAVIRUS | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |
| CN-1292697-A | Anti-viral compound | LILLY CO ELI (US) | 2001-04-25 | — | — | CN | disclosed |
| EP-1077701-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059587-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-11-25 | — | — | WO | disclosed |