Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.50 |
| ▸ | CES1 | P23141 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23301921 | 1.00 | CES2 (0.50) | CES2CES1KDM4EITGB2ICAM1 | |
| SCHEMBL1669004 | 0.86 | CES2 (0.64) | CES2CES1ITGB2ICAM1ITGAL | |
| SCHEMBL1669003 | 0.86 | CES2 (0.64) | CES2CES1ITGB2ICAM1ITGAL | |
| SCHEMBL11039504 | 0.84 | CES2 (0.49) | CES2CES1KDM4EITGB2ICAM1 | |
| SCHEMBL5255790 | 0.83 | CES2 (0.43) | CES2CES1KDM4EITGB2ICAM1 | |
| SCHEMBL11139560 | 0.80 | CXCL8 (0.45) | CES2CES1KDM4EITGB2ICAM1 | |
| SCHEMBL28852475 | 0.80 | CES2 (0.41) | CES2CES1KDM4EITGB2ICAM1 | |
| SCHEMBL29723949 | 0.80 | CES2 (0.45) | CES2CES1LMNAGAARIPK1 | |
| SCHEMBL23301730 | 0.80 | CES2 (0.45) | CES2CES1LMNAGAARIPK1 | |
| SCHEMBL13616663 | 0.78 | LMNA (0.41) | KDM4ELMNAMAPK1ALDH1A1FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4051671-A1 | FLUORINATED QUINOLINE, QUINOXALINE AND BENZO[B][1,4]OXAZINE DERIVATIVES AS DIHYDROOROTATE DEHYDROGENASE (DHODH) INHIBITORS FOR THE TREATMENT OF CANCER, AUTOIMMUNE AND INFLAMMATORY DISEASES | Janssen Biotech, Inc. (US) | 2022-09-07 | — | — | EP | disclosed |
| CN-114630826-A | Fluorinated quinoline, quinoxaline and benzo [ b ] [1,4] oxazine derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors for the treatment of cancer, autoimmune and inflammatory diseases | 詹森生物科技公司 | 2022-06-14 | — | — | CN | disclosed |