Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8149596 | 0.98 | MEN1 (0.54) | MEN1KMT2AHTTPOLBNPC1 | |
| SCHEMBL5066732 | 0.80 | MEN1 (0.59) | MEN1KMT2AHTTPOLBNPC1 | |
| SCHEMBL16863115 | 0.78 | MEN1 (0.35) | MEN1KMT2AHTTPOLBNPC1 | |
| SCHEMBL16866790 | 0.78 | NOS3 (0.39) | MEN1KMT2AHTTPOLBNPC1 | |
| SCHEMBL12789272 | 0.77 | MEN1 (0.60) | MEN1KMT2AHTTPOLBNPC1 | |
| SCHEMBL12789269 | 0.77 | NPC1 (0.56) | MEN1KMT2AHTTPOLBNPC1 | |
| SCHEMBL20448926 | 0.75 | HTT (0.35) | MEN1KMT2AHTTPOLBNPC1 | |
| SCHEMBL22520937 | 0.74 | KMT2A (0.53) | MEN1KMT2AHTTPOLBNPC1 | |
| SCHEMBL16116499 | 0.74 | ALDH1A1 (0.44) | MEN1KMT2AHTTPOLBNPC1 | |
| SCHEMBL12789271 | 0.73 | HTT (0.48) | MEN1KMT2AHTTPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3036231-B1 | SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF | JUBILANT BIOSYS LTD (IN) | 2020-02-26 | — | — | EP | disclosed |
| EP-3036231-B1 | SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF | JUBILANT BIOSYS LTD (IN) | 2020-02-26 | — | — | EP | disclosed |
| US-10273224-B2 | Substituted pyrimidine compounds, compositions and medicinal applications thereof | JUBILANT BIOSYS LIMITED (IN) | 2019-04-30 | — | — | US | disclosed |
| US-10273224-B2 | Substituted pyrimidine compounds, compositions and medicinal applications thereof | JUBILANT BIOSYS LIMITED (IN) | 2019-04-30 | — | — | US | disclosed |
| US-20180298009-A1 | Fused Pyrazole Derivatives As Kinase Inhibitors | UCB BIOPHARMA SPRL (BE) | 2018-10-18 | — | — | US | disclosed |
| EP-3356367-A1 | FUSED PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB Biopharma SPRL (BE) | 2018-08-08 | — | — | EP | disclosed |
| US-20170002011-A1 | BENZENE SULFONAMIDES AS CCR9 INHIBITORS | NORGINE B.V. (NL) | 2017-01-05 | — | — | US | disclosed |
| US-20170002011-A1 | BENZENE SULFONAMIDES AS CCR9 INHIBITORS | NORGINE B.V. (NL) | 2017-01-05 | — | — | US | disclosed |
| US-20170002011-A1 | BENZENE SULFONAMIDES AS CCR9 INHIBITORS | NORGINE B.V. (NL) | 2017-01-05 | — | — | US | disclosed |
| EP-3087074-A1 | BENZENE SULFONAMIDES AS CCR9 INHIBITORS | Norgine BV (NL) | 2016-11-02 | — | — | EP | disclosed |
| EP-3036231-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF | Jubilant Biosys Ltd. (IN) | 2016-06-29 | — | — | EP | disclosed |
| WO-2015097122-A1 | BENZENE SULFONAMIDES AS CCR9 INHIBITORS | NORGINE B.V. (NL) | 2015-07-02 | — | — | WO | disclosed |
| WO-2015097122-A1 | BENZENE SULFONAMIDES AS CCR9 INHIBITORS | NORGINE B.V. (NL) | 2015-07-02 | — | — | WO | disclosed |
| WO-2015025197-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF | JUBILANT BIOSYS LIMITED (IN) | 2015-02-26 | — | — | WO | disclosed |
| WO-2015025197-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF | JUBILANT BIOSYS LIMITED (IN) | 2015-02-26 | — | — | WO | disclosed |
| EP-0847271-B1 | PYRAZOLO-(1,5-a)-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND HAIR DYES CONTAINING THESE | OREAL (FR) | 2002-05-02 | — | — | EP | disclosed |
| US-5856320-A | ANTIBIOTIC RESISTANT STAPYLOCOCCUS | KATAYAMA SEIYAKUSYO CO., LTD. (JP) | 1999-01-05 | — | — | US | disclosed |
| EP-0847271-A1 | PYRAZOLO-(1,5-a)-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND HAIR DYES CONTAINING THESE | L'OREAL (FR) | 1998-06-17 | — | — | EP | disclosed |
| WO-1997049378-A1 | PYRAZOLO-(1,5-a)-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND HAIR DYES CONTAINING THESE | L'OREAL (FR) | 1997-12-31 | — | — | WO | disclosed |
| EP-0771803-A1 | Pyrazolo(1,5-a)pyrimidinium substituted cephem derivatives, their preparation and their use as antimicrobial agents | KATAYAMA SEIYAKUSYO CO. Ltd. (JP) | 1997-05-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180298009-A1 | Fused Pyrazole Derivatives As Kinase Inhibitors | PI4KA, PI4K2B, PI4KB | MEN1 3280/4885KMT2A 2326/4885HTT 4824/4885 |
| US-20170002011-A1 | BENZENE SULFONAMIDES AS CCR9 INHIBITORS | CCR9, CCR1, CCR4 | MEN1 4883/4885KMT2A 2961/4885HTT 4683/4885 |
| US-10273224-B2 | Substituted pyrimidine compounds, compositions and medicinal applications thereof | TYMP, EGFR, TK1 | MEN1 4787/4885KMT2A 4738/4885HTT 3318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.