Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.50 |
| ▸ | MERTK | Q12866 | 1/20 | 0.50 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | PRKCA | P17252 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | ALPG | P10696 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CCR5 | P51681 | 1/20 | 0.49 |
| ▸ | CCR8 | P51685 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27542221 | 0.82 | PLAU (0.58) | KDM4ETP53ALOX15MAPK1SMN1; SMN2 | |
| SCHEMBL7467181 | 0.81 | ABL1 (0.54) | FLT3ABL1BCRPRKCAKDM4E | |
| SCHEMBL28654499 | 0.78 | ULK1 (0.50) | FLT3TYRO3MERTKGAS6KDM4E | |
| SCHEMBL7470857 | 0.76 | ABL1 (0.63) | ABL1BCRPRKCAMAPK1SMN1; SMN2 | |
| SCHEMBL2819228 | 0.76 | CDK4 (0.54) | ABL1BCRPRKCAKDM4ELMNA | |
| SCHEMBL4825274 | 0.76 | BRD4 (0.47) | FLT3ABL1PRKCACCNB2CDK1 | |
| SCHEMBL2994968 | 0.75 | AURKA (0.62) | ABL1BCRPRKCAMAPK1SYK | |
| SCHEMBL15158474 | 0.75 | ATM (0.57) | FLT3TYRO3MERTKGAS6KDM4E | |
| SCHEMBL3756370 | 0.74 | IKBKB (0.53) | FLT3TYRO3ABL1SYK | |
| SCHEMBL6545045 | 0.74 | ULK1 (0.55) | KDM4ELMNATP53ALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | claimed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | claimed |