Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.54 |
| ▸ | BCR | P11274 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PRKCA | P17252 | 3/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | CCR4 | P51679 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.45 |
| ▸ | ULK1 | O75385 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475168 | 0.81 | CCNB2 (0.55) | ABL1BCRSRCSMN1; SMN2KDM4E | |
| SCHEMBL7465982 | 0.81 | FLT3 (0.50) | ABL1BCRSMN1; SMN2KDM4EPRKCA | |
| SCHEMBL3756370 | 0.81 | IKBKB (0.53) | ABL1PIK3CGPIK3CAPIK3CBMAPK8 | |
| SCHEMBL4825274 | 0.80 | BRD4 (0.47) | ABL1PRKCAPIK3CGPIK3CAPIK3CB | |
| SCHEMBL16390986 | 0.79 | IKBKB (0.47) | KDM4EPIK3CGPIK3CAPIK3CBMAPK8 | |
| SCHEMBL4817889 | 0.79 | TRPV1 (0.62) | ABL1BCRSRCPRKCA | |
| SCHEMBL7473241 | 0.79 | ABL1 (0.53) | ABL1BCRSRCPRKCAPIK3CG | |
| SCHEMBL7462149 | 0.78 | ABL1 (0.49) | ABL1BCRSRCPRKCAPIK3CG | |
| SCHEMBL7469488 | 0.78 | CAMKK2 (0.70) | ABL1BCRMAPTSMN1; SMN2KDM4E | |
| SCHEMBL27542221 | 0.78 | PLAU (0.58) | NPC1MAPTCASP3RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | claimed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | claimed |
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |