Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | TACR2 | P21452 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SHBG | P04278 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TST | Q16762 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29092450 | 0.98 | MAPT (0.50) | MAPTALDH1A1ESR1ADRA2AADORA3 | |
| SCHEMBL12844536 | 0.86 | GPR84 (0.42) | MAPTALDH1A1LMNAGPR84MGLL | |
| SCHEMBL16056885 | 0.79 | L3MBTL1 (0.49) | MAPTGPR84FAAHMGLL | |
| SCHEMBL5269793 | 0.79 | HRH1 (0.44) | HTR2A | |
| SCHEMBL30563780 | 0.75 | HPGD (0.39) | MAPTALDH1A1KDM4EHSD17B10ACHE | |
| SCHEMBL10568240 | 0.73 | ESR1 (0.73) | ALDH1A1ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL181089 | 0.73 | ESR1 (0.73) | ALDH1A1ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL24060739 | 0.73 | GAA (0.41) | MAPTALDH1A1LMNAHIF1AGPR84 | |
| SCHEMBL21459417 | 0.73 | HRH3 (0.50) | ALDH1A1HTR2CHTR2A | |
| SCHEMBL23256099 | 0.73 | HTR2A (0.39) | ALDH1A1SLC6A2CYP3A4HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0140375-B1 | ALKOXYIMINO ETHER DERIVATIVES OF 5-ACYL-2(1H)-PYRIDINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-23 | — | — | EP | claimed |
| EP-0140375-A2 | Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-05-08 | — | — | EP | claimed |
| CN-104168768-B | The method of preparation Cgrp receptor antagonist | 默沙东公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-103328478-B | Piperidinone carboxamide azaindane CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-10-07 | — | — | CN | disclosed |
| CN-102099036-B | Compounds and methods for treating inflammatory and fibrotic conditions | INTERMUNE INC | 2015-05-27 | — | — | CN | disclosed |
| CN-104168768-A | Process for making cgrp receptor antagonists | MERCK SHARP | 2014-11-26 | — | — | CN | disclosed |
| CN-103328478-A | Piperidinone carboxamide azaindane cgrp receptor antagonists | MERCK SHARP & DOHME | 2013-09-25 | — | — | CN | disclosed |
| US-5428045-A | 5-acyl-2-(1H)-pyridinoes | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | disclosed |
| US-5428045-A | 5-acyl-2-(1H)-pyridinoes | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | disclosed |
| US-5212315-A | Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-05-18 | — | — | US | disclosed |
| US-5212315-A | Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-05-18 | — | — | US | disclosed |
| EP-0140375-A2 | Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-05-08 | — | — | EP | disclosed |
| EP-0140375-A2 | Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-05-08 | — | — | EP | disclosed |
| EP-0140375-A2 | Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-05-08 | — | — | EP | disclosed |
| EP-0124089-A1 | Novel 5-acyl-2-(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-11-07 | — | — | EP | disclosed |
| EP-0124089-A1 | Novel 5-acyl-2-(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-11-07 | — | — | EP | disclosed |
| EP-0124089-A1 | Novel 5-acyl-2-(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-11-07 | — | — | EP | disclosed |
| EP-0124090-A1 | 5-Acyl-2-(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-11-07 | — | — | EP | disclosed |
| EP-0124090-A1 | 5-Acyl-2-(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-11-07 | — | — | EP | disclosed |
| EP-0124090-A1 | 5-Acyl-2-(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-11-07 | — | — | EP | disclosed |