Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.61 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | BCR | P11274 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474820 | 0.83 | ALDH1A1 (0.41) | MAPK14ADORA2AADORA1CD274SCN9A | |
| SCHEMBL5322574 | 0.82 | MAPK14 (0.61) | MAPK14LMNACD274WNT1DYRK1A | |
| Hydrochloric Acid SCHEMBL7468024 | 0.81 | MAPK14 (0.60) | MAPK14MAPK1CD274WNT1DYRK1A | |
| SCHEMBL5321309 | 0.81 | MAPK14 (0.61) | MAPK14ADORA2AADORA1 | |
| Hydrochloric Acid SCHEMBL7466695 | 0.80 | MAPK14 (0.60) | MAPK14ADORA2AADORA1 | |
| SCHEMBL7474200 | 0.80 | MAPK14 (0.58) | MAPK14GRM5MAPK1 | |
| SCHEMBL5321287 | 0.79 | HTR7 (0.47) | MAPK14CD274SCN9AWNT1DYRK1A | |
| SCHEMBL7475939 | 0.77 | FKBP1A (0.53) | MAPK14LMNARAB9A | |
| SCHEMBL7475479 | 0.76 | MAP3K14 (0.39) | MAPK14 | |
| SCHEMBL6157440 | 0.76 | MAPK14 (1.00) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218346-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021591-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-29 | — | — | WO | disclosed |