Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8649179 | 0.85 | PTGES (0.39) | PTGES | |
| SCHEMBL8784394 | 0.84 | HRH4 (0.35) | HRH4PTGESNQO2PGK1GSK3B | |
| SCHEMBL8784365 | 0.82 | HRH4 (0.34) | HRH4PTGESNQO2PGK1GSK3B | |
| SCHEMBL7468650 | 0.82 | HRH4 (0.34) | HRH4PTGESNQO2PGK1GSK3B | |
| SCHEMBL7467268 | 0.80 | GLP1R (0.34) | HRH4PTGESNQO2 | |
| SCHEMBL8784616 | 0.80 | TLR8 (0.35) | HRH4PTGESNQO2PGK1 | |
| SCHEMBL7470559 | 0.79 | HRH4 (0.32) | HRH4PTGESPGK1GSK3BMAP4K2 | |
| SCHEMBL7466793 | 0.78 | KCNH2 (0.32) | NQO2PGK1GSK3BMAP4K2 | |
| SCHEMBL7473964 | 0.77 | HRH4 (0.39) | HRH4PTGESNQO2PGK1GSK3B | |
| SCHEMBL8784916 | 0.76 | PTGES (0.32) | HRH4PTGESNQO2PGK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783495-B1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LTD (GB) | 2002-02-27 | — | — | EP | disclosed |
| EP-0781279-B1 | QUINOXALINEDIONE NMDA RECEPTOR ANTAGONISTS | PFIZER LTD (GB) | 2001-06-13 | — | — | EP | disclosed |
| US-5852016-A | Quinoxaline derivatives useful in therapy | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| US-5783572-A | TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER INC. (US) | 1998-07-21 | — | — | US | disclosed |
| EP-0783495-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | Pfizer Limited (GB) | 1997-07-16 | — | — | EP | disclosed |
| EP-0781279-A1 | QUINOXALINEDIONE NMDA RECEPTOR ANTAGONISTS | Pfizer Limited (GB) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996009295-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |
| WO-1996008485-A1 | QUINOXALINEDIONE NMDA RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 1996-03-21 | — | — | WO | disclosed |