Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 8/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | NQO2 | P16083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470559 | 0.88 | HRH4 (0.32) | GLP1RHRH4PTGES | |
| SCHEMBL7468298 | 0.81 | KMT2A (0.37) | PTGES | |
| SCHEMBL7466499 | 0.80 | HRH4 (0.35) | HRH4PTGESNQO2 | |
| SCHEMBL8784394 | 0.80 | HRH4 (0.35) | HRH4PTGESNQO2 | |
| SCHEMBL7468650 | 0.77 | HRH4 (0.34) | HRH4PTGESNQO2 | |
| SCHEMBL8784365 | 0.77 | HRH4 (0.34) | HRH4PTGESPDCD1LG2CD274NQO2 | |
| SCHEMBL8809914 | 0.77 | MTNR1A (0.33) | GLP1R | |
| SCHEMBL7473579 | 0.75 | GLP1R (0.35) | GLP1RHRH4PTGESLRRK2NQO2 | |
| SCHEMBL7466587 | 0.75 | CCR4 (0.36) | GLP1RHRH4LRRK2SMN1; SMN2HIF1A | |
| SCHEMBL8784616 | 0.75 | TLR8 (0.35) | HRH4PTGESPDCD1LG2CD274NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783495-B1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LTD (GB) | 2002-02-27 | — | — | EP | disclosed |
| US-5852016-A | Quinoxaline derivatives useful in therapy | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0783495-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | Pfizer Limited (GB) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996009295-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |