Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | ESRRG | P62508 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | ESRRB | O95718 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL751441 | 0.99 | OPRM1 (0.33) | OPRM1OPRD1CRHBPCRHR2TRPV1 | |
| SCHEMBL745512 | 0.92 | OPRM1 (0.34) | OPRM1OPRD1CRHBPCRHR2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL747110 | 0.92 | OPRM1 (0.34) | OPRM1OPRD1CRHBPCRHR2SIGMAR1 | |
| SCHEMBL746554 | 0.91 | TP53 (0.34) | OPRM1OPRD1SIGMAR1TP53CYP1A2 | |
| Hydrochloric Acid SCHEMBL748806 | 0.90 | TP53 (0.33) | OPRM1OPRD1SIGMAR1TP53CYP1A2 | |
| SCHEMBL745501 | 0.89 | TMEM97 (0.39) | OPRM1OPRD1CRHBPCRHR2SIGMAR1 | |
| SCHEMBL745516 | 0.88 | PARP1 (0.35) | OPRM1OPRD1TRPV1HSP90AA1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL752637 | 0.88 | TMEM97 (0.38) | OPRM1OPRD1CRHBPCRHR2SIGMAR1 | |
| SCHEMBL748282 | 0.88 | TP53 (0.39) | CRHBPCRHR2TRPV1TP53ESRRG | |
| Hydrochloric Acid SCHEMBL746670 | 0.87 | PARP1 (0.35) | OPRM1OPRD1TRPV1HSP90AA1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | claimed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | claimed |
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | disclosed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | disclosed |