Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466761 | 1.00 | MMP2 (0.36) | MMP2MMP13MDM2CYP2A6GRM4 | |
| SCHEMBL7061656 | 0.87 | MMP2 (0.39) | MMP2MMP13CYP2A6ANPEPHDAC3 | |
| SCHEMBL6741376 | 0.87 | MMP2 (0.39) | MMP2MMP13CYP2A6ANPEPHDAC3 | |
| SCHEMBL6740820 | 0.85 | MMP13 (0.43) | MMP2MMP13CYP2A6HDAC3HDAC1 | |
| SCHEMBL6740817 | 0.85 | MMP13 (0.43) | MMP2MMP13CYP2A6HDAC3HDAC1 | |
| SCHEMBL6733651 | 0.85 | HDAC4 (0.42) | MMP2MMP13CYP2A6ANPEP | |
| SCHEMBL6733654 | 0.85 | HDAC4 (0.42) | MMP2MMP13CYP2A6ANPEP | |
| SCHEMBL6739244 | 0.84 | MMP2 (0.39) | MMP2MMP13CYP2A6ANPEPHDAC1 | |
| SCHEMBL6739240 | 0.84 | MMP2 (0.39) | MMP2MMP13CYP2A6ANPEPHDAC1 | |
| SCHEMBL6738949 | 0.83 | MEP1B (0.41) | MMP2MMP13CYP2A6HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244616-A1 | (HETERO)BICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES | SmithKline Beecham plc (GB) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047874-A1 | (HETERO)BICYCLYMETHANESULFONYLAMINO-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-07-05 | — | — | WO | disclosed |