Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5868942 | 0.88 | ERCC5 (0.44) | ERCC5FEN1ALDH1A1MAPK14VNN1 | |
| SCHEMBL7065166 | 0.82 | VCP (0.45) | RAB9AGSK3BLMNA | |
| SCHEMBL5868908 | 0.82 | PLAU (0.45) | ERCC5FEN1ALDH1A1HDAC2KMT2A | |
| SCHEMBL5868787 | 0.81 | HDAC1 (0.42) | ERCC5FEN1ALDH1A1KMT2AMEN1 | |
| SCHEMBL5869023 | 0.81 | HDAC1 (0.42) | ERCC5FEN1ALDH1A1KMT2AMEN1 | |
| SCHEMBL7459196 | 0.80 | MAPK14 (0.48) | ALDH1A1MAPK14VNN1NPC1RAB9A | |
| SCHEMBL7463263 | 0.80 | GPR139 (0.45) | ALDH1A1VNN1KMT2ARAB9AGSK3B | |
| SCHEMBL5869030 | 0.80 | GSK3B (0.40) | ALDH1A1PLAUSMN1; SMN2HPGDGSK3B | |
| SCHEMBL7459390 | 0.79 | GSK3B (0.46) | VNN1KMT2ARAB9AGSK3BLMNA | |
| SCHEMBL7465211 | 0.79 | GSK3B (0.40) | ALDH1A1VNN1RAB9AKDM4EGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224175-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029012-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |